Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | CDC25B | P30305 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.39 |
| ▸ | CDC25A | P30304 | 1/20 | 0.39 |
| ▸ | CDC25C | P30307 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | GALR2 | O43603 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012337 | 0.90 | MAPT (0.48) | MAPTMEN1MAPK1KMT2ATSHR | |
| SCHEMBL7415121 | 0.89 | SMN1; SMN2 (0.46) | MAPTMEN1MAPK1KMT2APOLB | |
| Ethylene SCHEMBL7413517 | 0.86 | SMN1; SMN2 (0.44) | MAPTMEN1MAPK1KMT2APOLB | |
| SCHEMBL29220976 | 0.82 | MAPT (0.50) | MAPTMEN1MAPK1KMT2ATSHR | |
| SCHEMBL30954344 | 0.82 | MAPT (0.50) | MAPTMEN1MAPK1KMT2ATSHR | |
| SCHEMBL7407879 | 0.81 | SMN1; SMN2 (0.44) | MAPTMEN1MAPK1KMT2APOLB | |
| Ethylene SCHEMBL7411102 | 0.80 | SMN1; SMN2 (0.43) | MAPTMEN1MAPK1KMT2APOLB | |
| SCHEMBL7412813 | 0.80 | TRPV1 (0.45) | MAPTMEN1KMT2ATSHRPOLB | |
| SCHEMBL18285205 | 0.78 | TSHR (0.56) | MAPTMEN1MAPK1KMT2ATSHR | |
| SCHEMBL6656676 | 0.78 | MEN1 (0.68) | MAPTMEN1MAPK1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327631-A2 | Fused heterocyclic compounds, their production and use as angiotensin II antagonists | Takeda Chemical Industries, Ltd. (JP) | 2003-07-16 | — | — | EP | disclosed |
| EP-0518033-B1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-5389641-A | Fused heterocyclic compounds, having angiotensin II antagonistic activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0518033-A1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-12-16 | — | — | EP | disclosed |