Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006379 | 1.00 | HTR6 (0.44) | HTR6HSD11B1ALDH1A1KMT2AMAPT | |
| SCHEMBL2064235 | 0.84 | KDM2B (0.36) | HTR6HSD11B1ALDH1A1KMT2AMAPT | |
| SCHEMBL8385549 | 0.79 | HTR6 (0.44) | HTR6ALDH1A1KMT2AMEN1 | |
| SCHEMBL7485451 | 0.79 | HTR6 (0.57) | HTR6ALDH1A1KMT2AMAPT | |
| SCHEMBL7005429 | 0.75 | HTR6 (0.58) | HTR6 | |
| SCHEMBL7005431 | 0.75 | HTR6 (0.58) | HTR6 | |
| SCHEMBL2064415 | 0.74 | BTK (0.35) | HTR6KDM2B | |
| SCHEMBL7004526 | 0.74 | HTR6 (0.59) | HTR6 | |
| SCHEMBL7004521 | 0.74 | HTR6 (0.59) | HTR6 | |
| SCHEMBL3132568 | 0.74 | HTR6 (0.41) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105393-B1 | BICYCLIC PIPERIDINE AND PIPERAZINE COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | claimed |
| US-6251893-B1 | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | NPS ALLELIX CORP. (CA) | 2001-06-26 | — | — | US | claimed |