Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.34 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006630 | 1.00 | MEN1 (0.37) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL7003831 | 0.93 | MEN1 (0.45) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL7003833 | 0.93 | MEN1 (0.45) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL7002781 | 0.82 | CCNT1 (0.39) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL7002779 | 0.82 | CCNT1 (0.39) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL7005277 | 0.82 | HTR1A (0.37) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL7005264 | 0.82 | HTR1A (0.37) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL7004692 | 0.79 | CDK7 (0.38) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL7004689 | 0.79 | CDK7 (0.38) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL6998414 | 0.79 | CDK7 (0.39) | MEN1KMT2AKDM4EALDH1A1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1081149-B1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6372749-B1 | PHARMACOLOGICAL EFFECTS SUCH AS ANALGESIC ACTION, INHIBITORY EFFECT ON NITROGEN MONOXIDE SYNTHETASE AND THE LIKE AND ARE USEFUL AS ANALGESICS. | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2002-04-16 | — | — | US | disclosed |
| EP-1081149-A1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-03-07 | — | — | EP | disclosed |