Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 16/20 | 1.00 |
| ▸ | CDK2 | P24941 | 8/20 | 0.68 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.68 |
| ▸ | CDK7 | P50613 | 5/20 | 0.68 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.68 |
| ▸ | CDK9 | P50750 | 4/20 | 0.68 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.68 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.68 |
| ▸ | CCNH | P51946 | 3/20 | 0.68 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.68 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.68 |
| ▸ | CLK2 | P49760 | 2/20 | 0.68 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.68 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.68 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.68 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.68 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.68 |
| ▸ | CCNK | O75909 | 2/20 | 0.68 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.68 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (Rs)-Roscovitine SCHEMBL172593 | 0.81 | CDK1 (1.00) | CDK1CDK2CDK5CDK7CCNE1 | |
| SCHEMBL3445122 | 0.81 | CDK1 (0.69) | CDK1CDK2CDK5CDK7CCNE1 | |
| Seliciclib SCHEMBL94728 | 0.81 | CDK1 (1.00) | CDK1CDK2CDK5CDK7CCNE1 | |
| (S)-Roscovitine SCHEMBL2907488 | 0.81 | CDK1 (1.00) | CDK1CDK2CDK5CDK7CCNE1 | |
| SCHEMBL3444679 | 0.81 | CDK1 (0.69) | CDK1CDK2CDK5CDK7CCNE1 | |
| (Rs)-Roscovitine SCHEMBL15163619 | 0.81 | CDK1 (1.00) | CDK1CDK2CDK5CDK7CCNE1 | |
| (S)-Roscovitine SCHEMBL29415376 | 0.81 | CDK1 (1.00) | CDK1CDK2CDK5CDK7CCNE1 | |
| SCHEMBL28232483 | 0.79 | CDK2 (0.84) | CDK1CDK2CDK5CDK7CCNE1 | |
| SCHEMBL3445313 | 0.79 | CDK2 (0.71) | CDK1CDK2CDK5CDK7CCNE1 | |
| SCHEMBL17450135 | 0.79 | CDK2 (1.00) | CDK1CDK2CDK5CDK7CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030191086-A1 | Substituted nitrogen heterocyclic derivatives and pharmaceutical use thereof | USTAV EXPERIMENTALNI BOTANIKY AV CR | 2003-10-09 | — | — | US | disclosed |
| EP-1147108-B1 | SUBSTITUTED NITROGEN HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL USE THEREOF | USTAV EX BOTAN AKADEMIE VED CE (CZ) | 2003-08-13 | — | — | EP | disclosed |
| US-6552192-B1 | Inhibiting cyclin dependent kinase proteins, viruses, and immunostimulation; antimitotic, antiviral, anticancinogenic, antidegenerative, immunosuppressive | USTAU EXPERIMENTALNI BOTANIKY AV-CR (CZ) | 2003-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030191086-A1 | Substituted nitrogen heterocyclic derivatives and pharmaceutical use thereof | CDK4, CDK5, CCNI | CDK1 6/4885CDK2 11/4885CDK5 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.