SCHEMBL7006788

SCHEMBL7006788

COc1ccc(-c2c(CN)n(C)c(=O)c3ccc(Cl)cc23)cc1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 11/20 0.74
KCNA5 P22460 2/20 0.54
KCNH2 Q12809 2/20 0.54
CA1 P00915 3/20 0.50
CA2 P00918 3/20 0.50
CA12 O43570 1/20 0.50
CA3 P07451 1/20 0.50
CA4 P22748 1/20 0.50
CA6 P23280 1/20 0.50
CA5A P35218 1/20 0.50
CA7 P43166 1/20 0.50
CA9 Q16790 1/20 0.50
CA13 Q8N1Q1 1/20 0.50
CA14 Q9ULX7 1/20 0.50
CA5B Q9Y2D0 1/20 0.50
CYP3A4 P08684 2/20 0.46
MAP2 P11137 1/20 0.44
GABRP O00591 1/20 0.42
GABRD O14764 1/20 0.42
GABRA1 P14867 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5240250 0.99 DPP4 (0.72) DPP4KCNA5KCNH2CA1CA2
SCHEMBL5238796 0.89 DPP4 (0.58) DPP4KCNA5KCNH2CA1CA2
SCHEMBL5240310 0.88 DPP4 (0.57) DPP4KCNA5KCNH2CA1CA2
SCHEMBL7555668 0.87 DPP4 (0.73) DPP4KCNA5KCNH2
Hydrochloric Acid SCHEMBL5238032 0.86 DPP4 (0.71) DPP4KCNA5KCNH2
SCHEMBL6110970 0.85 DPP4 (0.77) DPP4KCNA5KCNH2CA1CA2
SCHEMBL7004422 0.85 DPP4 (0.77) DPP4KCNA5KCNH2
SCHEMBL5232770 0.85 DPP4 (1.00) DPP4KCNA5KCNH2
Hydrochloric Acid SCHEMBL5236244 0.84 DPP4 (0.76) DPP4KCNA5KCNH2CA1CA2
Hydrochloric Acid SCHEMBL5239422 0.84 DPP4 (0.76) DPP4KCNA5KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1355886-A1 FUSED HETEROCYCLIC COMPOUNDS Takeda Chemical Industries, Ltd. (JP) 2003-10-29 EP disclosed
WO-2002062764-A1 FUSED HETEROCYCLIC COMPOUNDS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-08-15 WO disclosed