Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 3/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013917 | 0.90 | MEN1 (0.45) | ROCK2RORCCNR1CNR2LMNA | |
| SCHEMBL7009565 | 0.90 | KCNQ3 (0.48) | ROCK2RORCCNR1CNR2LMNA | |
| SCHEMBL7010531 | 0.90 | TP53 (0.44) | ROCK2RORCCNR1CNR2LMNA | |
| Hydrochloric Acid SCHEMBL7007356 | 0.89 | TP53 (0.43) | ROCK2RORCCNR1CNR2LMNA | |
| Hydrochloric Acid SCHEMBL7016604 | 0.89 | KCNQ3 (0.48) | ROCK2RORCCNR1CNR2LMNA | |
| SCHEMBL7008605 | 0.88 | RORC (0.42) | ROCK2RORCCNR1CNR2LMNA | |
| SCHEMBL7009997 | 0.88 | MEN1 (0.52) | ROCK2RORCLMNATP53MAPT | |
| SCHEMBL7009661 | 0.88 | RORC (0.49) | ROCK2RORC | |
| Hydrochloric Acid SCHEMBL7008692 | 0.88 | RORC (0.41) | ROCK2RORCCNR1CNR2LMNA | |
| Hydrochloric Acid SCHEMBL7016934 | 0.87 | MEN1 (0.51) | ROCK2RORCLMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | claimed |
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |