Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 20/20 | 1.00 |
| ▸ | HTR1D | P28221 | 13/20 | 1.00 |
| ▸ | HTR1B | P28222 | 12/20 | 1.00 |
| ▸ | HTR1A | P08908 | 11/20 | 1.00 |
| ▸ | HTR2A | P28223 | 2/20 | 1.00 |
| ▸ | HTR2C | P28335 | 2/20 | 1.00 |
| ▸ | HTR1E | P28566 | 2/20 | 1.00 |
| ▸ | HTR4 | Q13639 | 2/20 | 1.00 |
| ▸ | HTR6 | P50406 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015988 | 0.92 | HTR1F (1.00) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7011770 | 0.91 | HTR1F (0.83) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7005835 | 0.90 | HTR1F (0.82) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7011869 | 0.90 | HTR1F (1.00) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7009046 | 0.89 | HTR1F (1.00) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7006579 | 0.89 | HTR1F (1.00) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7013589 | 0.89 | HTR1F (0.80) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7009030 | 0.89 | HTR1F (0.79) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7005319 | 0.89 | HTR1F (0.79) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7009231 | 0.88 | HTR1F (1.00) | HTR1FHTR1DHTR1BHTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842934-B1 | 5-HT1F agonists | LILLY CO ELI (US) | 2003-10-29 | — | — | EP | claimed |
| EP-1028955-B1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM PLC (GB) | 2003-07-16 | — | — | EP | claimed |
| EP-0916669-B1 | Processes and intermediates for the preparation of Pyrrolo(3,2-b)pyridine | LILLY CO ELI (US) | 2003-04-09 | — | — | EP | claimed |
| EP-1296982-A1 | 1-(HETEROARYL-PHENYL)-CONDENSED PYRAZOL DERIVATIVES AS FACTOR XA INHIBITORS | Bristol-Myers Squibb Pharma Company (US) | 2003-04-02 | — | — | EP | claimed |
| WO-2002000655-A1 | 1 - (HETEROARYL-PHENYL) - CONDENSED PYRAZOL DERIVATIVES AS FACTOR XA INHIBITORS | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2002-01-03 | — | — | WO | claimed |
| US-6150525-A | Pyrrolo [3,2-b]pyridine processes and intermediates | ELI LILLY AND COMPANY (US) | 2000-11-21 | — | — | US | claimed |
| EP-0916669-A2 | Processes and intermediates for the preparation of Pyrrolo(3,2-b)pyridine | ELI LILLY AND COMPANY (US) | 1999-05-19 | — | — | EP | claimed |
| EP-0842934-A1 | 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-05-20 | — | — | EP | claimed |
| EP-0842934-B1 | 5-HT1F agonists | LILLY CO ELI (US) | 2003-10-29 | — | — | EP | disclosed |
| EP-0916669-B1 | Processes and intermediates for the preparation of Pyrrolo(3,2-b)pyridine | LILLY CO ELI (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-1296982-A1 | 1-(HETEROARYL-PHENYL)-CONDENSED PYRAZOL DERIVATIVES AS FACTOR XA INHIBITORS | Bristol-Myers Squibb Pharma Company (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000655-A1 | 1 - (HETEROARYL-PHENYL) - CONDENSED PYRAZOL DERIVATIVES AS FACTOR XA INHIBITORS | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2002-01-03 | — | — | WO | disclosed |
| EP-1082958-A2 | 5-HT1F agonists in chronic pain | ELI LILLY AND COMPANY (US) | 2001-03-14 | — | — | EP | disclosed |
| US-6150525-A | Pyrrolo [3,2-b]pyridine processes and intermediates | ELI LILLY AND COMPANY (US) | 2000-11-21 | — | — | US | disclosed |
| US-5998622-A | ANALGESICS; ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | ELI LILLY AND COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0916669-A2 | Processes and intermediates for the preparation of Pyrrolo(3,2-b)pyridine | ELI LILLY AND COMPANY (US) | 1999-05-19 | — | — | EP | disclosed |
| EP-0842934-A1 | 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-05-20 | — | — | EP | disclosed |