Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 19/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013828 | 0.85 | PLA2G1B (0.67) | PLA2G1B | |
| SCHEMBL8028219 | 0.85 | PLA2G1B (0.55) | PLA2G1BKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL8022570 | 0.83 | PLA2G1B (0.48) | PLA2G1BKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL8012905 | 0.82 | PLA2G1B (0.60) | PLA2G1B | |
| SCHEMBL7010964 | 0.78 | PLA2G1B (0.47) | PLA2G1BMEN1KMT2A | |
| SCHEMBL7013364 | 0.77 | PLA2G1B (0.63) | PLA2G1BKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL7013371 | 0.77 | PLA2G1B (0.63) | PLA2G1BKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL7015597 | 0.77 | PLA2G1B (0.54) | PLA2G1BKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL8024688 | 0.77 | PLA2G1B (0.57) | PLA2G1B | |
| SCHEMBL8022761 | 0.77 | PLA2G1B (0.66) | PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |