SCHEMBL7007857

SCHEMBL7007857

O=C(O)C(=O)Cc1cc(F)c(F)cc1F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
ALDH1A1 P00352 2/20 0.37
CYP3A4 P08684 2/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2C19 P33261 1/20 0.37
KDM4E B2RXH2 1/20 0.37
MEN1 O00255 1/20 0.37
MAPT P10636 1/20 0.37
HPGD P15428 1/20 0.37
KMT2A Q03164 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
PTPN1 P18031 2/20 0.36
ERCC5 P28715 1/20 0.36
FEN1 P39748 1/20 0.36
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
CA4 P22748 2/20 0.35
DPP4 P27487 6/20 0.34
MMP2 P08253 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30529258 1.00 HDAC1 (0.39) HDAC1HDAC8ALDH1A1CYP3A4CYP1A2
SCHEMBL332576 0.82 CXCL8 (0.43) HDAC1HDAC8MEN1KMT2ADPP4
SCHEMBL29362137 0.82 CXCL8 (0.43) HDAC1HDAC8MEN1KMT2ADPP4
SCHEMBL29140954 0.80 CXCL8 (0.42) HDAC1HDAC8MEN1KMT2ADPP4
SCHEMBL30734413 0.80 CXCL8 (0.42) HDAC1HDAC8MEN1KMT2ADPP4
SCHEMBL11035311 0.79 CA1 (0.38) ALDH1A1CYP3A4CYP1A2CYP2C19KDM4E
Hydrochloric Acid SCHEMBL27770183 0.79 HDAC1 (0.37) HDAC1HDAC8CA1CA2CA4
Lithium Ion SCHEMBL31634833 0.78 CA1 (0.40) HDAC1HDAC8CA1CA2CA4
SCHEMBL17675533 0.78 MAPK8 (0.44) ALDH1A1KDM4ESMN1; SMN2
SCHEMBL29726367 0.78 MAPK8 (0.44) ALDH1A1KDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1313708-A1 QUINOLINE ANTIBACTERIAL COMPOUNDS AND METHODS OF USE THEREOF CHIRON CORPORATION (US) 2003-05-28 EP disclosed
WO-2002018345-A1 QUINOLINE ANTIBACTERIAL COMPOUNDS AND METHODS OF USE THEREOF CHIRON CORPORATION (US) 2002-03-07 WO disclosed