Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007876 | 0.71 | ALDH1A1 (0.46) | KDM4ERAB9ANPC1HSP90AA1ALDH1A1 | |
| SCHEMBL7007879 | 0.68 | KDM4E (0.50) | KDM4EHSP90AA1ALDH1A1LMNAMEN1 | |
| SCHEMBL13749494 | 0.67 | KDM4E (0.57) | KDM4ERAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL1006040 | 0.66 | KDM4E (0.68) | KDM4ERAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL19680294 | 0.66 | KDM4E (0.57) | KDM4ERAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL17781294 | 0.66 | KDM4E (0.49) | KDM4ERAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL10204204 | 0.66 | PDE2A (0.53) | KDM4ERAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL7101654 | 0.66 | ALDH1A1 (0.46) | KDM4ERAB9ANPC1HSP90AA1ALDH1A1 | |
| SCHEMBL5809049 | 0.65 | ALDH1A1 (0.47) | KDM4EHSP90AA1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL20697060 | 0.65 | KDM4E (0.64) | KDM4ERAB9ANPC1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327631-A2 | Fused heterocyclic compounds, their production and use as angiotensin II antagonists | Takeda Chemical Industries, Ltd. (JP) | 2003-07-16 | — | — | EP | disclosed |
| EP-0518033-B1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-5389641-A | Fused heterocyclic compounds, having angiotensin II antagonistic activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0518033-A1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-12-16 | — | — | EP | disclosed |