Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 13/20 | 0.44 |
| ▸ | ITGAV | P06756 | 13/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.38 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007936 | 0.93 | ITGB3 (0.51) | ITGB3ITGAVITGA2B | |
| SCHEMBL2836903 | 0.86 | ITGB3 (0.56) | ITGB3ITGAVITGA2BMAPTALDH1A1 | |
| SCHEMBL2836649 | 0.86 | ITGB3 (0.57) | ITGB3ITGAVITGA2BMAPTKDM4E | |
| SCHEMBL2837824 | 0.81 | ITGB3 (0.66) | ITGB3ITGAVITGA2B | |
| SCHEMBL2838053 | 0.80 | ITGB3 (0.67) | ITGB3ITGAVITGA2B | |
| SCHEMBL2841463 | 0.79 | ITGB3 (0.56) | ITGB3ITGAVITGA2BALDH1A1LMNA | |
| SCHEMBL2838617 | 0.79 | ITGB3 (0.58) | ITGB3ITGAVITGA2BKCNK3KCNK9 | |
| SCHEMBL2836137 | 0.77 | ITGB3 (0.57) | ITGB3ITGAVITGA2B | |
| SCHEMBL2841958 | 0.74 | ITGB3 (0.54) | ITGB3ITGAVITGA2BKCNK3KCNK9 | |
| SCHEMBL2836209 | 0.74 | ITGB3 (0.68) | ITGB3ITGAVITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1282602-A1 | PROPANOIC ACID DERIVATIVES AS INTEGRIN RECEPTOR ANTAGONISTS | Pharmacia Italia S.p.A. (IT) | 2003-02-12 | — | — | EP | claimed |
| WO-2001087840-A1 | PROPANOIC ACID DERIVATIVES AS INTEGRIN RECEPTOR ANTAGONISTS | PHARMACIA ITALIA S.P.A. (IT) | 2001-11-22 | — | — | WO | claimed |