Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31715213 | 0.85 | NPC1 (0.64) | NPC1LMNAALDH1A1RAB9AKDM4E | |
| SCHEMBL173434 | 0.83 | NPC1 (0.68) | NPC1LMNAALDH1A1RAB9AKDM4E | |
| SCHEMBL4242279 | 0.82 | NPC1 (0.61) | NPC1LMNAALDH1A1RAB9AKDM4E | |
| SCHEMBL24920108 | 0.81 | NPC1 (0.56) | NPC1LMNAALDH1A1RAB9AKDM4E | |
| SCHEMBL24452557 | 0.80 | NPC1 (0.65) | NPC1LMNAALDH1A1RAB9AKDM4E | |
| SCHEMBL19208815 | 0.79 | NPC1 (0.57) | NPC1LMNAALDH1A1RAB9AKDM4E | |
| SCHEMBL7105351 | 0.79 | NPC1 (0.64) | NPC1LMNAALDH1A1RAB9AKDM4E | |
| SCHEMBL28543588 | 0.78 | SMN1; SMN2 (0.39) | NPC1LMNASMN1; SMN2 | |
| SCHEMBL13522588 | 0.78 | HPGD (0.66) | NPC1LMNAALDH1A1RAB9AKDM4E | |
| SCHEMBL31352167 | 0.78 | NPC1 (0.62) | NPC1LMNAALDH1A1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327631-A2 | Fused heterocyclic compounds, their production and use as angiotensin II antagonists | Takeda Chemical Industries, Ltd. (JP) | 2003-07-16 | — | — | EP | disclosed |
| EP-0518033-B1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-5389641-A | Fused heterocyclic compounds, having angiotensin II antagonistic activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0518033-A1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-12-16 | — | — | EP | disclosed |