Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 3/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL6633678 | 0.99 | S1PR3 (0.48) | S1PR3LMNATSHRADRA2ACYP2D6 | |
| SCHEMBL4130038 | 0.81 | S1PR3 (0.71) | S1PR3LMNATSHRADRA2ACYP2D6 | |
| SCHEMBL6630656 | 0.80 | S1PR3 (0.55) | S1PR3LMNATSHRADRA2ACYP2D6 | |
| SCHEMBL6630391 | 0.80 | S1PR3 (0.52) | S1PR3LMNATSHRADRA2ACYP2D6 | |
| Iodide SCHEMBL6627950 | 0.80 | S1PR3 (0.47) | S1PR3LMNATSHRADRA2ACYP2D6 | |
| SCHEMBL6630509 | 0.79 | S1PR3 (0.54) | S1PR3LMNATSHRADRA2ACYP2D6 | |
| SCHEMBL4125056 | 0.77 | S1PR3 (0.78) | S1PR3LMNAADRA2AHTR2BWDR5 | |
| SCHEMBL6630953 | 0.74 | S1PR3 (0.65) | S1PR3LMNATSHRADRA2ACYP2D6 | |
| SCHEMBL6628554 | 0.72 | S1PR3 (0.49) | S1PR3LMNATSHRADRA2ACYP2D6 | |
| SCHEMBL4421524 | 0.70 | S1PR3 (0.56) | S1PR3LMNATSHRADRA2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368352-A1 | CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS | Pfizer Limited (GB) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002074774-A1 | CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS | PFIZER LIMITED (GB) | 2002-09-26 | — | — | WO | disclosed |