Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.58 |
| ▸ | NPY1R | P25929 | 9/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6634796 | 0.84 | HRH3 (0.59) | HRH3NPY1RKDM4EALDH1A1ACP1 | |
| SCHEMBL6633644 | 0.80 | HRH3 (0.59) | HRH3NPY1R | |
| SCHEMBL6636097 | 0.80 | HRH3 (0.59) | HRH3NPY1R | |
| SCHEMBL6635339 | 0.79 | HRH3 (0.60) | HRH3NPY1R | |
| SCHEMBL6635801 | 0.77 | HRH3 (0.61) | HRH3NPY1RACP1 | |
| SCHEMBL6635925 | 0.77 | HRH3 (0.62) | HRH3NPY1R | |
| SCHEMBL28770567 | 0.76 | CYP3A4 (0.49) | HRH3NPY1RACP1 | |
| SCHEMBL8090027 | 0.76 | HRH3 (0.67) | HRH3KDM4ENPC1ALDH1A1POLB | |
| SCHEMBL8091834 | 0.75 | HRH3 (0.66) | HRH3KDM4ENPC1ALDH1A1POLB | |
| SCHEMBL8086750 | 0.74 | HRH3 (0.65) | HRH3KDM4ENPC1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268479-A1 | PHENYL-SUBSTITUTED INDOLIZINE DERIVATIVES AND THEIR USE AS HISTAMINE H3 LIGANDS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-01-02 | — | — | EP | claimed |
| WO-2001074814-A1 | PHENYL-SUBSTITUTED INDOLIZINE DERIVATIVES AND THEIR USE AS HISTAMINE H3 LIGANDS | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2001-10-11 | — | — | WO | claimed |
| EP-1268479-A1 | PHENYL-SUBSTITUTED INDOLIZINE DERIVATIVES AND THEIR USE AS HISTAMINE H3 LIGANDS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074814-A1 | PHENYL-SUBSTITUTED INDOLIZINE DERIVATIVES AND THEIR USE AS HISTAMINE H3 LIGANDS | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2001-10-11 | — | — | WO | disclosed |