Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090027 | 0.96 | HRH3 (0.67) | HRH3NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8091834 | 0.94 | HRH3 (0.66) | HRH3NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1847594 | 0.78 | RAB9A (0.61) | HRH3NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL29089761 | 0.76 | ALDH1A1 (0.62) | HRH3NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL7306229 | 0.75 | LSS (0.56) | HRH3NPC1ALDH1A1RAB9AMAPK1 | |
| SCHEMBL942764 | 0.75 | ALDH1A1 (0.65) | HRH3NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL38657287 | 0.75 | NPC1 (0.56) | HRH3NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL7008263 | 0.74 | HRH3 (0.58) | HRH3NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL13394694 | 0.73 | HRH3 (0.65) | HRH3NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8086737 | 0.73 | RAB9A (0.76) | HRH3NPC1ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103724-A | EXHIBIT MAINLY ANTIPSYCHOTIC EFFECTS, E.G., SCHIZOPHRENIA, ORGANIC MENTAL DISORDERS, AFFECTIVE DISORDERS, ANXIETY, PERSONALITY DISORDERS; NEUROLEPTIC ACTIVITIY; ATYPICAL ANTIPSYCHOTICS, COGNITION ACTIVATORS, ANTIDEPRESSANTS; | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2000-08-15 | — | — | US | disclosed |
| EP-0935599-A1 | 2-METHOXYPHENYLPIPERAZINE DERIVATIVES | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1999-08-18 | — | — | EP | disclosed |
| WO-1998018797-A1 | 2-METHOXYPHENYLPIPERAZINE DERIVATIVES | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1998-05-07 | — | — | WO | disclosed |