Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | PDE6D | O43924 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6634804 | 0.86 | HRH3 (0.47) | HRH3ALDH1A1KDM4ESLC6A2SLC6A4 | |
| SCHEMBL6636105 | 0.82 | HRH3 (0.47) | HRH3ALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL6633646 | 0.82 | HRH3 (0.46) | HRH3ALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL6637128 | 0.82 | HRH3 (0.49) | HRH3ALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL6635807 | 0.80 | HRH3 (0.49) | HRH3NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL6635934 | 0.78 | HRH3 (0.50) | HRH3ALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL28770569 | 0.77 | CYP2D6 (0.38) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4462917 | 0.74 | SLC6A2 (0.35) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7008263 | 0.73 | HRH3 (0.58) | HRH3NPC1ALDH1A1POLBMAPT | |
| SCHEMBL6642823 | 0.72 | HRH3 (0.56) | HRH3NPC1ALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268479-A1 | PHENYL-SUBSTITUTED INDOLIZINE DERIVATIVES AND THEIR USE AS HISTAMINE H3 LIGANDS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-01-02 | — | — | EP | claimed |
| WO-2001074814-A1 | PHENYL-SUBSTITUTED INDOLIZINE DERIVATIVES AND THEIR USE AS HISTAMINE H3 LIGANDS | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2001-10-11 | — | — | WO | claimed |