Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.32 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008496 | 0.83 | POLB (0.33) | POLBHSD17B10KDM4EALDH1A1HRH3 | |
| SCHEMBL3589415 | 0.80 | POLB (0.42) | SMN1; SMN2POLBHSD17B10KDM4EALDH1A1 | |
| SCHEMBL65329 | 0.78 | HRH3 (0.47) | POLBHSD17B10KDM4EALDH1A1HRH3 | |
| SCHEMBL4324356 | 0.75 | L3MBTL3 (0.38) | POLBHSD17B10KDM4EALDH1A1HRH3 | |
| SCHEMBL65252 | 0.74 | POLB (0.52) | POLBHSD17B10KDM4EALDH1A1HRH3 | |
| SCHEMBL2553841 | 0.74 | HRH3 (0.44) | POLBHSD17B10KDM4EALDH1A1HRH3 | |
| SCHEMBL3768409 | 0.74 | POLB (0.56) | SMN1; SMN2POLBHSD17B10KDM4EALDH1A1 | |
| SCHEMBL1464487 | 0.73 | L3MBTL3 (0.55) | POLBHSD17B10KDM4EALDH1A1HRH3 | |
| SCHEMBL5889057 | 0.73 | USP2 (0.47) | SMN1; SMN2POLBKDM4EALDH1A1HPGD | |
| SCHEMBL21140974 | 0.73 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341540-A2 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002045652-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2002-06-13 | — | — | WO | disclosed |