Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.56 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.51 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3441906 | 1.00 | MTNR1A (0.56) | MTNR1ACREBBPSMYD3MAPTGAA | |
| Hydrochloric Acid SCHEMBL3441459 | 0.98 | MTNR1A (0.55) | MTNR1ACREBBPSMYD3MAPTGAA | |
| Hydrochloric Acid SCHEMBL3441458 | 0.98 | MTNR1A (0.55) | MTNR1ACREBBPSMYD3MAPTGAA | |
| SCHEMBL7951734 | 0.85 | MTNR1A (0.55) | MTNR1ACREBBPSMYD3MAPTGAA | |
| SCHEMBL3108670 | 0.81 | MTNR1A (0.55) | MTNR1ACREBBPSMYD3MAPTGAA | |
| SCHEMBL20870486 | 0.81 | MTNR1A (0.60) | MTNR1ACREBBPSMYD3MAPTGAA | |
| SCHEMBL7149457 | 0.81 | MTNR1A (0.56) | MTNR1ACREBBPSMYD3MAPTGAA | |
| SCHEMBL22262591 | 0.81 | MTNR1A (0.60) | MTNR1ACREBBPSMYD3MAPTGAA | |
| SCHEMBL2124605 | 0.81 | MTNR1A (0.52) | MTNR1ACREBBPSMYD3MAPTGAA | |
| SCHEMBL3115244 | 0.81 | MTNR1A (0.52) | MTNR1ACREBBPSMYD3MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922315-A | CATHEPSIN K INHIBITOR AND APPLICATION THEREOF | 广东东阳光药业有限公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-105646122-B | Compound, its preparation method and the application of a kind of methyl mercapto containing difluoro | 中国科学院上海有机化学研究所 | 2017-11-07 | — | — | CN | disclosed |
| CN-107141293-A | Nitrogen-containing heterocyclic compound, preparation method, intermediate, composition and application | 上海医药集团股份有限公司 | 2017-09-08 | — | — | CN | disclosed |
| CN-106478564-A | Cathepsin K inhibitor and application thereof | 广东东阳光药业有限公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-106456574-A | Hybrid immunoglobulins containing non-peptide linkages | 丹尼尔·J·卡鹏 | 2017-02-22 | — | — | CN | disclosed |
| WO-2015040424-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AND THEIR USE AS PYRUVATE DEHYDROGENASE KINASE INHIBITORS | VERNALIS (R&D) LIMITED (GB) | 2015-03-26 | — | — | WO | disclosed |
| CN-102056919-B | Substituted sulfonamide derivatives | GRUENENTHAL GMBH | 2014-03-12 | — | — | CN | disclosed |
| US-8580965-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2013-11-12 | — | — | US | disclosed |
| US-8580965-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2013-11-12 | — | — | US | disclosed |
| US-8541573-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2013-09-24 | — | — | US | disclosed |
| EP-0642508-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-03-15 | — | — | EP | disclosed |
| CN-1098722-A | Tricyclic quinoxalinedione derivatives | SUMITOMO PHARMA (JP) | 1995-02-15 | — | — | CN | disclosed |
| EP-0627434-A1 | Tricyclic quinoxalinedione derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-12-07 | — | — | EP | disclosed |
| EP-0284395-B1 | NOVEL GLYCEROL DERIVATIVE AND ANTI-HYPERTENSIVE AGENT | NIPPON CHEMIPHAR CO., LTD. (JP) | 1993-06-23 | — | — | EP | disclosed |
| WO-1993008188-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1993-04-29 | — | — | WO | disclosed |
| US-5183811-A | Glycerol derivative and anti-hypertensive agent | NIPPON CHEMIPHAR CO., LTD. (JP) | 1993-02-02 | — | — | US | disclosed |
| CN-1017435-B | PROCESS FOR PREPARATION OF GLYCEROL DERIVATIVES | NIPPON CHEMIPHAR CO (JP) | 1992-07-15 | — | — | CN | disclosed |
| US-4962096-A | WITH REDUCED PLATELET AGGREGATING ACTION | NIPPON CHEMIPHAR CO., LTD. (JP) | 1990-10-09 | — | — | US | disclosed |
| CN-1030239-A | The preparation method of new glycerol derivative | NIPPON CHEMIPHAR CO (JP) | 1989-01-11 | — | — | CN | disclosed |
| EP-0284395-A2 | Novel glycerol derivative and anti-hypertensive agent | NIPPON CHEMIPHAR CO., LTD. (JP) | 1988-09-28 | — | — | EP | disclosed |