Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC16A1 | P53985 | 15/20 | 0.57 |
| ▸ | PDE1A | P54750 | 5/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.49 |
| ▸ | PDE2A | O00408 | 4/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.44 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6721723 | 0.87 | PDE2A (0.45) | SLC16A1PDE1APDE1BPDE1CPDE2A | |
| SCHEMBL7004749 | 0.81 | SLC16A1 (0.63) | SLC16A1CYP2C9CYP3A4MAPKAPK2CAMK2B | |
| SCHEMBL7010063 | 0.80 | SLC16A1 (0.69) | SLC16A1CYP2C9CYP3A4 | |
| SCHEMBL7005458 | 0.77 | SLC16A1 (0.60) | SLC16A1CYP2C9CYP3A4MAPKAPK2CAMK2B | |
| SCHEMBL7005435 | 0.77 | PDE1B (0.57) | SLC16A1PDE1APDE1BPDE1CPDE2A | |
| SCHEMBL7007944 | 0.76 | SLC16A1 (0.58) | SLC16A1CYP2C9CYP3A4MAPKAPK2CAMK2B | |
| SCHEMBL7005447 | 0.75 | SLC16A1 (0.61) | SLC16A1CYP2C9CYP3A4MAPKAPK2CAMK2B | |
| SCHEMBL7005376 | 0.75 | SLC16A1 (0.61) | SLC16A1CYP2C9CYP3A4MAPKAPK2CAMK2B | |
| SCHEMBL7007701 | 0.75 | SLC16A1 (0.51) | SLC16A1CYP2C9CYP3A4MAPKAPK2CAMK2B | |
| SCHEMBL7008682 | 0.74 | SLC16A1 (0.50) | SLC16A1CYP2C9CYP3A4MAPKAPK2CAMK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107973-B1 | NOVEL THIENO[2,3-d]PYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION AND USE THEREOF IN THERAPY | ASTRAZENECA AB (SE) | 2003-11-05 | — | — | EP | claimed |
| US-6300334-B1 | DRUGS FOR TREATMENT OF RESPIRATORY SYSTEM DISORDERS | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | claimed |
| EP-1107973-B1 | NOVEL THIENO[2,3-d]PYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION AND USE THEREOF IN THERAPY | ASTRAZENECA AB (SE) | 2003-11-05 | — | — | EP | disclosed |
| US-6300334-B1 | DRUGS FOR TREATMENT OF RESPIRATORY SYSTEM DISORDERS | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |
| EP-1107973-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012514-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |