Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 12/20 | 0.61 |
| ▸ | HTR1B | P28222 | 11/20 | 0.61 |
| ▸ | HTR1A | P08908 | 5/20 | 0.48 |
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | HTR2B | P41595 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HTR5A | P47898 | 4/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.45 |
| ▸ | HTR3B | O95264 | 2/20 | 0.45 |
| ▸ | HTR1E | P28566 | 2/20 | 0.45 |
| ▸ | HTR1F | P30939 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | HTR3A | P46098 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008669 | 1.00 | HTR1D (0.61) | HTR1DHTR1BHTR1AHTR2AHTR2B | |
| SCHEMBL7006008 | 0.85 | HTR1D (0.62) | HTR1DHTR1BMPO | |
| SCHEMBL7006006 | 0.82 | SLC6A4 (0.54) | HTR1DHTR1BSLC6A4HTR6 | |
| SCHEMBL7012884 | 0.81 | HTR1B (0.61) | HTR1DHTR1BHTR1AHTR6 | |
| SCHEMBL7011467 | 0.81 | HTR1B (0.61) | HTR1DHTR1BHTR1AHTR6 | |
| SCHEMBL7012887 | 0.81 | HTR1B (0.61) | HTR1DHTR1BHTR1AHTR6 | |
| SCHEMBL7006019 | 0.81 | HTR1B (0.61) | HTR1DHTR1BHTR1AHTR6 | |
| SCHEMBL7880763 | 0.80 | HTR1B (0.47) | HTR1DHTR1BHTR1ASLC6A4HTR6 | |
| SCHEMBL7006151 | 0.79 | HTR1D (0.63) | HTR1DHTR1BHTR1AHTR2AHTR2B | |
| SCHEMBL7006155 | 0.79 | HTR1D (0.63) | HTR1DHTR1BHTR1AHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098896-B1 | 5-BICYCLOINDOLE COMPOUNDS | NPS ALLELIX CORP (CA) | 2003-06-25 | — | — | EP | claimed |
| EP-1098896-B1 | 5-BICYCLOINDOLE COMPOUNDS | NPS ALLELIX CORP (CA) | 2003-06-25 | — | — | EP | disclosed |
| US-6329390-B1 | BIHETEROCYCLIC INDOLES AS ANALGESICS AND NERVOUS SYSTEM DISORDERS | NPS ALLELIX CORP. (CA) | 2001-12-11 | — | — | US | disclosed |