Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 2/20 | 0.57 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.56 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1749820 | 0.92 | PTPN11 (0.63) | PTPN11CREBBPGRM2ALDH1A1HPGD | |
| SCHEMBL6196393 | 0.88 | PTPN11 (0.57) | PTPN11CREBBPHDAC1HDAC8HDAC6 | |
| SCHEMBL5874111 | 0.87 | CREBBP (0.67) | PTPN11CREBBPKMT2AALDH1A1HPGD | |
| SCHEMBL7009423 | 0.86 | PTPN11 (0.56) | PTPN11CREBBPKMT2AALDH1A1HPGD | |
| SCHEMBL14972690 | 0.86 | PTPN11 (0.56) | PTPN11CREBBPKMT2AALDH1A1HPGD | |
| SCHEMBL7009493 | 0.85 | PTPN11 (0.54) | PTPN11CREBBPKMT2AALDH1A1HPGD | |
| SCHEMBL7644581 | 0.85 | HDAC1 (0.51) | CREBBPALDH1A1HPGDCA9HDAC1 | |
| SCHEMBL7011266 | 0.84 | PTPN11 (0.53) | PTPN11CREBBPKMT2AALDH1A1HPGD | |
| SCHEMBL2563466 | 0.84 | PTPN11 (0.53) | PTPN11CREBBPKMT2AALDH1A1HPGD | |
| SCHEMBL566516 | 0.83 | POLB (0.66) | PTPN11CREBBPKMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |
| US-6479520-B1 | REGULATING APOPTOSIS IN HUMAN CELLS WITH COMPOUNDS SUCH AS: 3-CYANO-6-(2-METHOXY-4-METHYLTHIOIPHENYL)-2(1H)-PYRIDINONE | CELL PATHWAYS, INC. | 2002-11-12 | — | — | US | disclosed |
| CN-1324359-A | Tricyclic carboxamides | SMITHKLINE BEECHAM PLC (GB) | 2001-11-28 | — | — | CN | disclosed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | disclosed |
| US-6046216-A | USEFUL TO INHIBIT THE GROWTH OF NEOPLASTIC CELLS. | CELL PATHWAYS, INC. (US) | 2000-04-04 | — | — | US | disclosed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | disclosed |
| EP-0428268-A2 | Pharmaceutical phenylpyridone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-05-22 | — | — | EP | disclosed |