Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKAR | P32238 | 5/20 | 0.44 |
| ▸ | CCKBR | P32239 | 5/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.41 |
| ▸ | NOTCH1 | P46531 | 6/20 | 0.39 |
| ▸ | NOTCH3 | Q9UM47 | 3/20 | 0.39 |
| ▸ | RBPJ | Q06330 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005901 | 0.92 | CCKAR (0.44) | CCKARCCKBRPSEN1PSEN2APH1B | |
| SCHEMBL7003908 | 0.90 | CCKBR (0.44) | CCKARCCKBRNOTCH1NOTCH3RBPJ | |
| SCHEMBL7009892 | 0.89 | CCKBR (0.43) | CCKARCCKBRNOTCH1NOTCH3RBPJ | |
| SCHEMBL7011891 | 0.88 | CCKBR (0.44) | CCKARCCKBRNOTCH1NOTCH3RBPJ | |
| SCHEMBL7012796 | 0.82 | CCKBR (0.44) | CCKARCCKBRNOTCH1NOTCH3RBPJ | |
| SCHEMBL4159805 | 0.74 | PSEN1 (0.67) | CCKARCCKBRPSEN1PSEN2APH1B | |
| SCHEMBL13904794 | 0.74 | PSEN1 (0.67) | CCKARCCKBRPSEN1PSEN2APH1B | |
| SCHEMBL7012788 | 0.74 | PSEN1 (0.37) | CCKARCCKBRPSEN1PSEN2APH1B | |
| SCHEMBL7013368 | 0.72 | CCKBR (0.49) | CCKARCCKBRNOTCH1RBPJMEN1 | |
| SCHEMBL7007597 | 0.72 | CCKBR (0.43) | CCKARCCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268450-A1 | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001092235-A1 | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-12-06 | — | — | WO | disclosed |