Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.72 |
| ▸ | TEK | Q02763 | 11/20 | 0.72 |
| ▸ | LCK | P06239 | 8/20 | 0.72 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 3/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | HCK | P08631 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2075266 | 0.84 | KDR (0.75) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL7005899 | 0.84 | TEK (1.00) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2075144 | 0.84 | KDR (0.74) | KDRTEKLCKSRCHPGD | |
| SCHEMBL7003822 | 0.81 | KDR (0.76) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL7004416 | 0.81 | KDR (0.77) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL7008114 | 0.80 | TEK (0.72) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2073069 | 0.80 | KDR (0.66) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL7005282 | 0.80 | TEK (0.69) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL7004771 | 0.80 | KDR (0.63) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL6464268 | 0.79 | TEK (0.70) | KDRTEKLCKSRCPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | claimed |
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | disclosed |
| EP-0970084-A1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-01-12 | — | — | EP | disclosed |
| US-6001839-A | Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |
| WO-1998041525-A1 | PYRROLO[2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 1998-09-24 | — | — | WO | disclosed |