Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.76 |
| ▸ | TEK | Q02763 | 15/20 | 0.76 |
| ▸ | LCK | P06239 | 12/20 | 0.76 |
| ▸ | SRC | P12931 | 3/20 | 0.63 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | HCK | P08631 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | ABL2 | P42684 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004416 | 0.87 | KDR (0.77) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2072184 | 0.87 | TEK (0.69) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL7005899 | 0.86 | TEK (1.00) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL7005282 | 0.86 | TEK (0.69) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2073278 | 0.84 | KDR (0.66) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2075821 | 0.83 | TEK (0.75) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2075266 | 0.82 | KDR (0.75) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL7008774 | 0.81 | KDR (0.72) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2075144 | 0.81 | KDR (0.74) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2074335 | 0.79 | KDR (0.76) | KDRTEKLCKSRCPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | claimed |
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6001839-A | Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |