Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 7/20 | 0.62 |
| ▸ | KDR | P35968 | 7/20 | 0.62 |
| ▸ | TEK | Q02763 | 7/20 | 0.62 |
| ▸ | SRC | P12931 | 9/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 5/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | ABL2 | P42684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009027 | 0.91 | LCK (0.72) | LCKKDRTEKSRCEGFR | |
| SCHEMBL7009870 | 0.90 | KDR (0.61) | LCKKDRTEKSRCEGFR | |
| SCHEMBL7006962 | 0.86 | LCK (0.83) | LCKKDRTEKSRCEGFR | |
| SCHEMBL7097902 | 0.85 | KDR (0.63) | LCKKDRTEKSRCEGFR | |
| SCHEMBL7011554 | 0.84 | KDR (0.64) | LCKKDRTEKSRCEGFR | |
| SCHEMBL7003841 | 0.81 | LCK (0.74) | LCKKDRTEKSRCEGFR | |
| SCHEMBL7009552 | 0.81 | LCK (0.65) | LCKKDRTEKSRCEGFR | |
| SCHEMBL7011559 | 0.80 | LCK (0.84) | LCKKDRTEKSRCEGFR | |
| SCHEMBL8145545 | 0.80 | KDR (0.56) | LCKKDRTEKSRCEGFR | |
| SCHEMBL7011982 | 0.80 | KDR (0.63) | LCKKDRTEKSRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | disclosed |
| EP-0970084-A1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-01-12 | — | — | EP | disclosed |
| US-6001839-A | Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |
| WO-1998041525-A1 | PYRROLO[2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 1998-09-24 | — | — | WO | disclosed |