Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | DRD3 | P35462 | 2/20 | 0.57 |
| ▸ | DRD5 | P21918 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PMM2 | O15305 | 1/20 | 0.43 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16110253 | 0.89 | MEN1 (0.60) | HPGDMEN1KMT2ADRD2DRD3 | |
| SCHEMBL28744553 | 0.82 | MEN1 (0.70) | MEN1KMT2ADRD2DRD3ALDH1A1 | |
| SCHEMBL29702930 | 0.82 | MEN1 (0.70) | MEN1KMT2ADRD2DRD3ALDH1A1 | |
| SCHEMBL16110147 | 0.81 | HPGD (0.59) | HPGDMEN1KMT2ADRD2DRD3 | |
| SCHEMBL6767398 | 0.81 | HPGD (0.68) | HPGDMEN1KMT2AALDH1A1CASP6 | |
| SCHEMBL6763292 | 0.79 | HPGD (0.70) | HPGDMEN1KMT2ADRD2DRD3 | |
| SCHEMBL16110144 | 0.79 | MEN1 (0.52) | HPGDMEN1KMT2ADRD2DRD3 | |
| SCHEMBL31422646 | 0.78 | HPGD (1.00) | HPGDMEN1KMT2ADRD2DRD3 | |
| SCHEMBL143970 | 0.78 | HPGD (1.00) | HPGDMEN1KMT2ADRD2DRD3 | |
| SCHEMBL6772536 | 0.78 | HPGD (0.68) | HPGDMEN1KMT2AALDH1A1CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | claimed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | claimed |