Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.42 |
| ▸ | JAK2 | O60674 | 6/20 | 0.42 |
| ▸ | JAK1 | P23458 | 6/20 | 0.42 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 4/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.37 |
| ▸ | CD38 | P28907 | 4/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL700926 | 0.85 | GAA (0.37) | JAK3JAK2JAK1GAATYK2 | |
| SCHEMBL692026 | 0.81 | PTK2 (0.45) | JAK2JAK1GAATYK2PTK2 | |
| SCHEMBL690617 | 0.81 | PTK2 (0.57) | JAK3JAK2JAK1GAATYK2 | |
| SCHEMBL2309262 | 0.77 | CD38 (0.40) | JAK3JAK2JAK1TYK2IRAK4 | |
| SCHEMBL704871 | 0.73 | JAK3 (0.42) | JAK3JAK2JAK1TYK2IRAK4 | |
| SCHEMBL1323795 | 0.73 | MAPK3 (0.56) | JAK3JAK2JAK1TYK2IRAK4 | |
| SCHEMBL691652 | 0.69 | PTK2 (0.57) | JAK3JAK2JAK1GAATYK2 | |
| SCHEMBL690303 | 0.69 | MAPK3 (0.56) | JAK2JAK1TYK2PTK2 | |
| SCHEMBL690657 | 0.69 | PTK2 (0.59) | JAK3JAK2JAK1TYK2PTK2 | |
| SCHEMBL691087 | 0.68 | PTK2 (0.60) | JAK2JAK1GAATYK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421537-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GlaxoSmithKline LLC (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010062578-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-06-03 | — | — | WO | disclosed |