Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.42 |
| ▸ | JAK2 | O60674 | 12/20 | 0.42 |
| ▸ | JAK1 | P23458 | 12/20 | 0.42 |
| ▸ | TYK2 | P29597 | 12/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | CD38 | P28907 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2309262 | 0.86 | CD38 (0.40) | JAK3JAK2JAK1TYK2IRAK4 | |
| SCHEMBL704872 | 0.82 | JAK3 (0.42) | JAK3JAK2JAK1TYK2PTK2 | |
| SCHEMBL691660 | 0.79 | MAPK3 (0.60) | JAK2JAK1TYK2PTK2MAPK8 | |
| SCHEMBL1292972 | 0.79 | PTK2 (0.64) | JAK3JAK2JAK1TYK2PTK2 | |
| SCHEMBL691696 | 0.78 | PTK2 (0.50) | JAK3JAK2JAK1TYK2PTK2 | |
| SCHEMBL3474620 | 0.78 | PTK2 (0.51) | JAK3JAK2JAK1TYK2IRAK4 | |
| SCHEMBL691691 | 0.76 | CD38 (0.48) | JAK3JAK2JAK1TYK2IRAK4 | |
| SCHEMBL700925 | 0.73 | JAK3 (0.42) | JAK3JAK2JAK1TYK2IRAK4 | |
| SCHEMBL29127270 | 0.73 | JAK2 (0.42) | JAK3JAK2JAK1TYK2MAP4K4 | |
| SCHEMBL691560 | 0.72 | MAPK1 (0.48) | JAK2JAK1TYK2PTK2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421537-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GlaxoSmithKline LLC (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010062578-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-06-03 | — | — | WO | disclosed |