Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.58 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | ROS1 | P08922 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008227 | 0.90 | ERBB2 (0.65) | EGFRERBB2ERBB4CHEK2ROS1 | |
| SCHEMBL7010037 | 0.81 | EGFR (0.55) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL3322433 | 0.81 | EGFR (0.72) | EGFRERBB2 | |
| SCHEMBL6767913 | 0.80 | ERBB2 (0.56) | EGFRERBB2ERBB4 | |
| SCHEMBL3321605 | 0.80 | EGFR (0.67) | EGFRERBB2GAKERBB4JAK3 | |
| SCHEMBL3324076 | 0.80 | EGFR (0.58) | EGFRERBB2GAKERBB4CHEK2 | |
| Hydrochloric Acid SCHEMBL6767733 | 0.80 | ERBB2 (0.56) | EGFRERBB2ERBB4 | |
| SCHEMBL7892279 | 0.79 | EGFR (0.56) | EGFRERBB2GAKERBB4CHEK2 | |
| SCHEMBL3321829 | 0.79 | EGFR (0.65) | EGFRERBB2GAKERBB4CHEK2 | |
| Hydrochloric Acid SCHEMBL7892473 | 0.79 | EGFR (0.55) | EGFRERBB2GAKERBB4CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912572-B1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2003-01-15 | — | — | EP | disclosed |