Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009446 | 1.00 | HTR6 (0.44) | HTR6ALDH1A1KCNH2HRH3DRD2 | |
| SCHEMBL2064417 | 0.78 | HTR6 (0.46) | HTR6ALDH1A1HRH3DRD2 | |
| SCHEMBL4673199 | 0.76 | HTR6 (0.50) | HTR6 | |
| SCHEMBL7014117 | 0.73 | SLC6A4 (0.56) | HTR6ALDH1A1HRH3 | |
| SCHEMBL7014120 | 0.73 | SLC6A4 (0.56) | HTR6ALDH1A1HRH3 | |
| SCHEMBL2065057 | 0.73 | HTR6 (0.46) | HTR6ALDH1A1HRH3DRD2 | |
| SCHEMBL7486142 | 0.73 | HTR6 (0.66) | HTR6DRD2 | |
| SCHEMBL8201464 | 0.73 | HTR6 (0.71) | HTR6 | |
| SCHEMBL8201461 | 0.73 | HTR6 (0.71) | HTR6 | |
| SCHEMBL2065542 | 0.72 | HTR6 (0.45) | HTR6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105393-B1 | BICYCLIC PIPERIDINE AND PIPERAZINE COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | claimed |
| US-6251893-B1 | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | NPS ALLELIX CORP. (CA) | 2001-06-26 | — | — | US | claimed |
| EP-1105393-A1 | BICYCLIC PIPERIDINE AND PIPERAZINE COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | NPS Allelix Corp. (CA) | 2001-06-13 | — | — | EP | claimed |
| WO-1999065906-A1 | BICYCLIC PIPERIDINE AND PIPERAZINE COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1999-12-23 | — | — | WO | claimed |
| EP-1105393-B1 | BICYCLIC PIPERIDINE AND PIPERAZINE COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | disclosed |
| US-6251893-B1 | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | NPS ALLELIX CORP. (CA) | 2001-06-26 | — | — | US | disclosed |
| EP-1105393-A1 | BICYCLIC PIPERIDINE AND PIPERAZINE COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | NPS Allelix Corp. (CA) | 2001-06-13 | — | — | EP | disclosed |
| WO-1999065906-A1 | BICYCLIC PIPERIDINE AND PIPERAZINE COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1999-12-23 | — | — | WO | disclosed |