Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7015757 | 0.99 | TP53 (0.47) | TP53LMNACNR1CNR2RORC | |
| SCHEMBL7010531 | 0.96 | TP53 (0.44) | TP53LMNACNR1CNR2RORC | |
| Hydrochloric Acid SCHEMBL7007356 | 0.95 | TP53 (0.43) | TP53LMNACNR1CNR2RORC | |
| SCHEMBL7008605 | 0.89 | RORC (0.42) | TP53LMNACNR1CNR2RORC | |
| Hydrochloric Acid SCHEMBL7008692 | 0.89 | RORC (0.41) | TP53LMNACNR1CNR2RORC | |
| SCHEMBL7009857 | 0.88 | RORC (0.41) | TP53LMNACNR1CNR2RORC | |
| SCHEMBL7012754 | 0.87 | RORC (0.44) | CNR1CNR2RORCNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7010712 | 0.87 | RORC (0.41) | TP53LMNACNR1CNR2RORC | |
| SCHEMBL7008091 | 0.86 | RORC (0.40) | TP53LMNACNR1CNR2RORC | |
| Hydrochloric Acid SCHEMBL7009820 | 0.86 | RORC (0.44) | CNR1CNR2RORCNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | claimed |
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |