Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.66 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.48 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.48 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009577 | 1.00 | MTNR1A (0.66) | MTNR1AMTNR1BGAAHDAC8THRB | |
| SCHEMBL124730 | 0.87 | MTNR1A (0.64) | MTNR1AMTNR1BHDAC8MEN1ALDH1A1 | |
| SCHEMBL124729 | 0.87 | MTNR1A (0.64) | MTNR1AMTNR1BHDAC8MEN1ALDH1A1 | |
| SCHEMBL7007021 | 0.85 | MTNR1A (0.62) | MTNR1AMTNR1BGAAHDAC8MEN1 | |
| SCHEMBL7007025 | 0.85 | MTNR1A (0.62) | MTNR1AMTNR1BGAAHDAC8MEN1 | |
| SCHEMBL7228521 | 0.83 | MTNR1A (0.59) | MTNR1AMTNR1BHDAC8 | |
| SCHEMBL7228520 | 0.83 | MTNR1A (0.59) | MTNR1AMTNR1BHDAC8 | |
| SCHEMBL10470091 | 0.82 | HDAC8 (0.46) | MTNR1AMTNR1BGAAHDAC8THRB | |
| SCHEMBL10470089 | 0.82 | HDAC8 (0.46) | MTNR1AMTNR1BGAAHDAC8THRB | |
| SCHEMBL10298599 | 0.80 | MTNR1A (0.62) | MTNR1AMTNR1BALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583319-B1 | Treating or preventing melatoninergic disorders | LES LABORATOIRES SERVIER (FR) | 2003-06-24 | — | — | US | disclosed |
| EP-0994102-B1 | Cyclic derivatives with a cycloalkylenic chain, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-03-19 | — | — | EP | disclosed |
| EP-0994102-A1 | Cyclic derivatives with a cycloalkylenic chain, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-04-19 | — | — | EP | disclosed |