Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.54 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 8/20 | 0.53 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5935590 | 1.00 | PIM1 (0.54) | PIM1PIM2MAOAMAOBHPGD | |
| SCHEMBL5935575 | 0.89 | MAOA (0.56) | PIM1PIM2MAOAMAOBHPGD | |
| SCHEMBL6359955 | 0.89 | MAOA (0.56) | PIM1PIM2MAOAMAOBHPGD | |
| SCHEMBL5935589 | 0.85 | HPGD (0.60) | PIM1PIM2MAOAMAOBHPGD | |
| SCHEMBL7010573 | 0.85 | HPGD (0.60) | PIM1PIM2MAOAMAOBHPGD | |
| SCHEMBL5935611 | 0.83 | KCNH2 (0.52) | HPGD | |
| SCHEMBL5935681 | 0.83 | PIM1 (0.56) | PIM1PIM2MAOAMAOBHPGD | |
| SCHEMBL7013434 | 0.83 | HPGD (0.62) | PIM1PIM2MAOAMAOBHPGD | |
| SCHEMBL5935568 | 0.83 | HPGD (0.62) | PIM1PIM2MAOAMAOBHPGD | |
| SCHEMBL6357256 | 0.82 | HPGD (0.61) | PIM1PIM2MAOAMAOBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958296-B1 | HETEROCYCLIC COMPOUNDS PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THE TREATMENT OF DIABETES AND RELATED DISEASES | REDDYS LAB LTD DR (IN) | 2003-07-30 | — | — | EP | claimed |
| US-6372750-B2 | COMPOUNDS SUCH AS 5-(4-(2-(2,4-DIMETHYL-6-OXO-1,6-DIHYDRO-1-PYRIMIDINYL)ETHOXY)PHENYL METHYL)THIZOLIDINE-2,4-DIONE MADE BY CYCLIZATION, CHEMICAL REDUCTION, HYDROLYSIS, AZOLIDINEDIONE DERIVATIVES | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2002-04-16 | — | — | US | claimed |