Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 13/20 | 0.72 |
| ▸ | LCK | P06239 | 13/20 | 0.72 |
| ▸ | KDR | P35968 | 11/20 | 0.72 |
| ▸ | SRC | P12931 | 8/20 | 0.69 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | HCK | P08631 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006180 | 0.91 | TEK (0.72) | TEKLCKKDRSRCFLT3 | |
| SCHEMBL7008419 | 0.85 | LCK (0.83) | TEKLCKKDRSRCLMNA | |
| SCHEMBL7009429 | 0.84 | LCK (0.75) | TEKLCKKDRSRCLMNA | |
| SCHEMBL7008467 | 0.84 | LCK (1.00) | TEKLCKKDRSRCLMNA | |
| SCHEMBL7006962 | 0.83 | LCK (0.83) | TEKLCKKDRSRCLMNA | |
| SCHEMBL7011559 | 0.83 | LCK (0.84) | TEKLCKKDRSRCLMNA | |
| SCHEMBL6861193 | 0.82 | LCK (1.00) | TEKLCKKDRSRCLMNA | |
| SCHEMBL7006502 | 0.82 | LCK (0.81) | TEKLCKKDRSRCLMNA | |
| SCHEMBL7013132 | 0.81 | KDR (0.69) | TEKLCKKDRSRCBTK | |
| SCHEMBL7005163 | 0.80 | SRC (0.81) | TEKLCKKDRSRCLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | claimed |
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6001839-A | Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |