SCHEMBL7009910

SCHEMBL7009910

Nc1nc(-n2cc(C(=O)O)c(=O)c3cc(F)c(NCC(O)CO)c(Cl)c32)c(F)cc1F

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 3/20 0.58
CYP3A4 P08684 2/20 0.58
PIM1 P11309 4/20 0.47
TOP1 P11387 4/20 0.35
TOP2A P11388 2/20 0.35
GSK3B P49841 3/20 0.33
EPHA2 P29317 1/20 0.33
FLT4 P35916 1/20 0.33
RARB P10826 1/20 0.33
TBXAS1 P24557 1/20 0.33
SLC6A3 Q01959 1/20 0.33
ALDH1A1 P00352 3/20 0.33
POLB P06746 3/20 0.33
LMNA P02545 2/20 0.33
KDM4E B2RXH2 2/20 0.33
HPGD P15428 1/20 0.33
XBP1 P17861 1/20 0.33
NFKB1 P19838 1/20 0.33
HTT P42858 1/20 0.33
NFKB2 Q00653 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Monoethanolamine SCHEMBL7006967 0.86 CYP2C9 (0.60) CYP2C9CYP3A4PIM1TOP1TOP2A
SCHEMBL7006829 0.86 CYP3A4 (0.60) CYP2C9CYP3A4PIM1TOP1TOP2A
SCHEMBL7005270 0.86 CYP2C9 (0.60) CYP2C9CYP3A4PIM1TOP1TOP2A
SCHEMBL7007355 0.84 CYP2C9 (0.60) CYP2C9CYP3A4PIM1TOP1TOP2A
SCHEMBL10018777 0.84 CYP3A4 (0.67) CYP2C9CYP3A4PIM1TOP1TOP2A
SCHEMBL7007305 0.84 CYP2C9 (0.66) CYP2C9CYP3A4PIM1TOP1TOP2A
SCHEMBL7004218 0.83 CYP2C9 (0.58) CYP2C9CYP3A4PIM1TOP1TOP2A
SCHEMBL7005816 0.82 CYP2C9 (0.57) CYP2C9CYP3A4PIM1TOP1TOP2A
SCHEMBL2670076 0.81 CYP2C9 (0.71) CYP2C9CYP3A4PIM1TOP1TOP2A
SCHEMBL14421859 0.80 CYP2C9 (0.66) CYP2C9CYP3A4PIM1TOP1TOP2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0945435-B1 NOVEL PYRIDONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT WAKUNAGA PHARMA CO LTD (JP) 2003-08-13 EP disclosed
US-6136823-A BACTERICIDES OR VIRICIDES WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) 2000-10-24 US disclosed
EP-0945435-A1 NOVEL PYRIDONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) 1999-09-29 EP disclosed