Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 2/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.46 |
| ▸ | APLNR | P35414 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7008344 | 0.99 | NAMPT (0.52) | NAMPTNPC1KCNQ3KCNQ2RORC | |
| SCHEMBL7009565 | 0.91 | KCNQ3 (0.48) | NAMPTNPC1KCNQ3KCNQ2RORC | |
| Hydrochloric Acid SCHEMBL7016604 | 0.90 | KCNQ3 (0.48) | NAMPTNPC1KCNQ3KCNQ2RORC | |
| SCHEMBL7009130 | 0.90 | KCNQ3 (0.50) | NAMPTNPC1KCNQ3KCNQ2RORC | |
| Hydrochloric Acid SCHEMBL7007973 | 0.89 | KCNQ3 (0.49) | NAMPTNPC1KCNQ3KCNQ2RORC | |
| SCHEMBL7012754 | 0.89 | RORC (0.44) | NAMPTNPC1RORCCNR1CNR2 | |
| SCHEMBL7012602 | 0.88 | MAPT (0.49) | CNR1CNR2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7009820 | 0.88 | RORC (0.44) | NAMPTNPC1RORCCNR1CNR2 | |
| Hydrochloric Acid SCHEMBL7014137 | 0.87 | MAPT (0.49) | CNR1CNR2MEN1KMT2A | |
| SCHEMBL7007350 | 0.86 | RORC (0.50) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | claimed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | claimed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | claimed |
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | disclosed |