Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.63 |
| ▸ | ADRA1D | P25100 | 12/20 | 0.63 |
| ▸ | HTR1B | P28222 | 12/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 12/20 | 0.63 |
| ▸ | ADRA1B | P35368 | 12/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 4/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013844 | 0.90 | HTR1A (0.62) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7007308 | 0.89 | HTR1A (0.61) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7013973 | 0.87 | HTR1A (0.58) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7013085 | 0.83 | GAA (0.58) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7014939 | 0.81 | HTR1A (0.63) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7665897 | 0.79 | HTR1A (0.75) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7012057 | 0.79 | HTR1A (0.61) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7012662 | 0.78 | HTR1A (0.52) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7014563 | 0.78 | HTR1A (0.53) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7007932 | 0.78 | HTR1A (0.60) | HTR1AADRA1DHTR1BADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988306-B1 | 3-SUBSTITUTED 3,4 DIHYDRO-THIENO 2, 3-D]PYRIMIDINE DERIVATIVES AND PRODUCTION AND USE OF THE SAME | ABBOTT GMBH & CO KG (DE) | 2003-07-09 | — | — | EP | disclosed |
| US-6387912-B1 | STROKE THERAPY | BASF AKTIENGESELLSCHAFT (DE) | 2002-05-14 | — | — | US | disclosed |
| EP-1140096-A1 | UTILIZATION OF PYRIMIDINE DERIVATIVES FOR PREVENTING AND TREATING CEREBRAL ISCHAEMIA | BASF AKTIENGESELLSCHAFT (DE) | 2001-10-10 | — | — | EP | disclosed |
| US-6159962-A | 3-substituted 3,4-dihydro-thieno[2,3-D]pyrimidine derivatives and production and use of the same | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-12 | — | — | US | disclosed |
| WO-2000041695-A1 | UTILIZATION OF PYRIMIDINE DERIVATIVES FOR PREVENTING AND TREATING CEREBRAL ISCHAEMIA | BASF AKTIENGESELLSCHAFT (DE) | 2000-07-20 | — | — | WO | disclosed |