Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.57 |
| ▸ | GSK3A | P49840 | 2/20 | 0.57 |
| ▸ | AURKA | O14965 | 5/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 8/20 | 0.51 |
| ▸ | IGF1R | P08069 | 4/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | CDK7 | P50613 | 4/20 | 0.46 |
| ▸ | CDK9 | P50750 | 4/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL699910 | 0.90 | CDK2 (0.52) | GSK3BGSK3AAURKAJAK2AURKB | |
| SCHEMBL701007 | 0.85 | HDAC1 (0.57) | AURKAAURKBCDK2IGF1RKCNH2 | |
| SCHEMBL7978513 | 0.81 | CDK2 (0.69) | GSK3BAURKAAURKBCDK2IGF1R | |
| SCHEMBL23245965 | 0.81 | CDK2 (0.48) | GSK3BGSK3AAURKAJAK2AURKB | |
| SCHEMBL29884067 | 0.81 | CDK2 (0.48) | GSK3BGSK3AAURKAJAK2AURKB | |
| SCHEMBL699813 | 0.78 | CDK2 (0.50) | JAK2CDK2IGF1RKCNH2CDK7 | |
| SCHEMBL29883521 | 0.77 | IGF1R (0.65) | CDK2IGF1RKCNH2CDK7CDK9 | |
| SCHEMBL23246020 | 0.77 | IGF1R (0.65) | CDK2IGF1RKCNH2CDK7CDK9 | |
| SCHEMBL12789980 | 0.76 | PKM (0.49) | CDK2IGF1RIRAK4 | |
| SCHEMBL27475477 | 0.75 | IRAK4 (0.55) | GSK3BCDK2IGF1RKCNH2CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124764-B2 | Fused heterocyclyc inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| EP-2303881-A2 | FUSED HETEROCYCLYC INHIBITORS OF HISTONE DEACETYLASE AND/OR CYCLIN-DEPENDENT KINASES | GILEAD SCIENCES, INC. (US) | 2011-04-06 | — | — | EP | disclosed |
| US-20100029638-A1 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. | 2010-02-04 | — | — | US | disclosed |
| WO-2010009155-A2 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | GILEAD COLORADO, INC. (US) | 2010-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029638-A1 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | HDAC1, HDAC11, HDAC7 | GSK3B 477/4885GSK3A 615/4885AURKA 123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.