Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ELANE | P08246 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | CASP7 | P55210 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7602321 | 0.83 | POLB (0.57) | SMN1; SMN2POLBALDH1A1ELANEKDM4E | |
| SCHEMBL7014741 | 0.82 | MEN1 (0.49) | SMN1; SMN2ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL7018791 | 0.82 | BACE1 (0.43) | KDM4EGAAHSD17B10 | |
| SCHEMBL22509709 | 0.80 | KDM4E (0.63) | SMN1; SMN2POLBALDH1A1ELANEKDM4E | |
| SCHEMBL9670132 | 0.78 | POLB (0.57) | SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL31277167 | 0.78 | PARG (0.56) | SMN1; SMN2ALDH1A1KDM4EMAPTHTT | |
| SCHEMBL7012534 | 0.77 | KDM4E (0.64) | POLBALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL1161309 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2POLBALDH1A1ELANEKDM4E | |
| SCHEMBL15071621 | 0.76 | HDAC6 (0.49) | SMN1; SMN2POLBALDH1A1ELANEKDM4E | |
| SCHEMBL27668568 | 0.76 | KDM4E (0.62) | POLBALDH1A1KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-5753664-A | ANTITUMOR AGENTS, PYRIMIDONES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |
| EP-0034529-B1 | TRIAZOLOQUINAZOLINONE DERIVATIVES AND THEIR ACID ADDITION SALTS, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1983-07-20 | — | — | EP | disclosed |
| US-4350695-A | Antihistaminic and bronchospasmolytic triazoloquinazolinones | ROUSSEL UCLAF (FR) | 1982-09-21 | — | — | US | disclosed |
| EP-0034529-A1 | Triazoloquinazolinone derivatives and their acid addition salts, their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1981-08-26 | — | — | EP | disclosed |