Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.45 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7018838 | 0.93 | MAPT (0.44) | MAPTLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8171487 | 0.92 | MAPT (0.46) | MAPTLMNAMEN1KMT2ASMN1; SMN2 | |
| Bicarbonate SCHEMBL7017197 | 0.86 | ALDH1A1 (0.47) | MAPTLMNAMEN1KMT2ASMN1; SMN2 | |
| Bicarbonate SCHEMBL7015314 | 0.86 | PDE5A (0.59) | MAPTLMNAMEN1KMT2ASMN1; SMN2 | |
| Bicarbonate SCHEMBL7018633 | 0.85 | MAPT (0.46) | MAPTLMNAMEN1KMT2ASMN1; SMN2 | |
| Bicarbonate SCHEMBL7016772 | 0.85 | MEN1 (0.42) | MAPTLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8183229 | 0.85 | PTPN12 (0.44) | MAPTLMNAMEN1KMT2ASMN1; SMN2 | |
| Bicarbonate SCHEMBL7013383 | 0.84 | ESR1 (0.44) | LMNAMEN1KMT2ASMN1; SMN2PDE5A | |
| SCHEMBL6711626 | 0.84 | MAPT (0.42) | MAPTLMNAMEN1KMT2ASMN1; SMN2 | |
| Bicarbonate SCHEMBL7018741 | 0.84 | KMT2A (0.51) | MAPTLMNAMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |