Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.54 |
| ▸ | TEK | Q02763 | 9/20 | 0.54 |
| ▸ | LCK | P06239 | 8/20 | 0.54 |
| ▸ | SRC | P12931 | 8/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.40 |
| ▸ | RET | P07949 | 3/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | HCK | P08631 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | YES1 | P07947 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | FGR | P09769 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012725 | 0.90 | LCK (0.58) | KDRTEKLCKSRCEGFR | |
| SCHEMBL7013132 | 0.89 | KDR (0.69) | KDRTEKLCKSRCEGFR | |
| SCHEMBL7011965 | 0.86 | KDR (0.54) | KDRTEKLCKSRCEGFR | |
| SCHEMBL7010611 | 0.85 | LCK (0.63) | KDRTEKLCKSRCEGFR | |
| SCHEMBL7007653 | 0.85 | LCK (0.63) | KDRTEKLCKSRCEGFR | |
| SCHEMBL7012365 | 0.84 | KDR (0.64) | KDRTEKLCKSRCEGFR | |
| SCHEMBL7012650 | 0.83 | LCK (0.74) | KDRTEKLCKSRCEGFR | |
| SCHEMBL7011523 | 0.83 | KDR (0.63) | KDRTEKLCKSRCEGFR | |
| SCHEMBL8128260 | 0.80 | KDR (0.51) | KDRTEKLCKSRCEGFR | |
| SCHEMBL7007578 | 0.79 | KDR (0.59) | KDRTEKLCKSRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | disclosed |
| EP-0970084-A1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-01-12 | — | — | EP | disclosed |
| US-6001839-A | Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |
| WO-1998041525-A1 | PYRROLO[2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 1998-09-24 | — | — | WO | disclosed |