Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.54 |
| ▸ | LCK | P06239 | 7/20 | 0.54 |
| ▸ | TEK | Q02763 | 7/20 | 0.54 |
| ▸ | SRC | P12931 | 9/20 | 0.51 |
| ▸ | EGFR | P00533 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 4/20 | 0.40 |
| ▸ | ABL2 | P42684 | 4/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.40 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8128260 | 0.93 | KDR (0.51) | KDRLCKTEKSRCEGFR | |
| SCHEMBL7011523 | 0.91 | KDR (0.63) | KDRLCKTEKSRCEGFR | |
| SCHEMBL7007578 | 0.90 | KDR (0.59) | KDRLCKTEKSRCEGFR | |
| SCHEMBL7014152 | 0.86 | KDR (0.54) | KDRLCKTEKSRCEGFR | |
| SCHEMBL7010879 | 0.86 | KDR (0.54) | KDRLCKTEKSRCEGFR | |
| SCHEMBL7013873 | 0.85 | KDR (0.63) | KDRLCKTEKSRCEGFR | |
| SCHEMBL7007563 | 0.84 | KDR (0.62) | KDRLCKTEKSRCEGFR | |
| SCHEMBL7012365 | 0.84 | KDR (0.64) | KDRLCKTEKSRCEGFR | |
| SCHEMBL7005538 | 0.83 | KDR (0.65) | KDRLCKTEKSRCEGFR | |
| SCHEMBL7004833 | 0.83 | KDR (0.62) | KDRLCKTEKSRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6001839-A | Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |