SCHEMBL7010950

SCHEMBL7010950

CC1(N)CN(c2c(F)cc3c(=O)c(C(=O)O)cn(-c4cc(N)c(F)cc4F)c3c2Cl)C1

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.54
CYP2C9 P11712 2/20 0.54
TOP2A P11388 12/20 0.46
TOP1 P11387 9/20 0.46
ALDH1A1 P00352 2/20 0.46
POLB P06746 2/20 0.46
CHRM2 P08172 1/20 0.46
CHRM1 P11229 1/20 0.46
OPRM1 P35372 1/20 0.46
OPRD1 P41143 1/20 0.46
KCNH2 Q12809 1/20 0.42
TOP2B Q02880 5/20 0.42
KDM4E B2RXH2 2/20 0.40
HSP90AA1 P07900 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19729373 0.90 CYP3A4 (0.48) CYP3A4CYP2C9TOP2ATOP1ALDH1A1
SCHEMBL6581505 0.90 KCNH2 (0.51) CYP3A4CYP2C9TOP2ATOP1ALDH1A1
SCHEMBL7013856 0.88 CYP3A4 (0.51) CYP3A4CYP2C9TOP2ATOP1ALDH1A1
SCHEMBL9144101 0.87 CYP3A4 (0.49) CYP3A4CYP2C9TOP2ATOP1ALDH1A1
SCHEMBL8483333 0.87 TOP1 (0.61) CYP3A4CYP2C9TOP2ATOP1ALDH1A1
SCHEMBL7008772 0.86 CYP3A4 (0.61) CYP3A4CYP2C9TOP2ATOP1ALDH1A1
SCHEMBL7004804 0.86 CYP3A4 (0.71) CYP3A4CYP2C9TOP2ATOP1ALDH1A1
SCHEMBL7009205 0.85 CYP3A4 (0.60) CYP3A4CYP2C9TOP2ATOP1ALDH1A1
SCHEMBL8482299 0.85 TOP2A (0.61) CYP3A4CYP2C9TOP2ATOP1ALDH1A1
SCHEMBL7007374 0.85 CYP3A4 (0.58) CYP3A4CYP2C9TOP2ATOP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787720-B1 PYRIDONECARBOXYLATE DERIVATIVE OR SALT THEREOF AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT WAKUNAGA SEIYAKU KK (JP) 2003-07-16 EP disclosed
US-5910498-A NOVEL COMPOUNDS HAVING REDUCED CYTOTOXICITY, PHOTOTOXICITY; TREATING BACTERIAL AND VIRAL INFECTIONS WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1999-06-08 US disclosed
EP-0787720-A1 NOVEL PYRIDONECARBOXYLATE DERIVATIVE OR SALT THEREOF AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1997-08-06 EP disclosed