SCHEMBL8483333

SCHEMBL8483333

CN1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(-c4cc(N)c(F)cc4F)c3c2Cl)CC1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TOP1 P11387 5/20 0.61
TOP2A P11388 5/20 0.61
KDM4E B2RXH2 8/20 0.55
CYP3A4 P08684 1/20 0.54
CYP2C9 P11712 1/20 0.54
ADRA2B P18089 1/20 0.52
MAPK1 P28482 1/20 0.52
ALDH1A1 P00352 6/20 0.52
HPGD P15428 4/20 0.52
HSD17B10 Q99714 3/20 0.52
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
LMNA P02545 1/20 0.50
ALB P02768 1/20 0.50
HRH3 Q9Y5N1 1/20 0.50
POLB P06746 2/20 0.49
TUBB4A P04350 1/20 0.49
TUBB P07437 1/20 0.49
TUBA3C P0DPH7 1/20 0.49
TUBA1B P68363 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8482299 0.89 TOP2A (0.61) TOP1TOP2AKDM4ECYP3A4CYP2C9
SCHEMBL7010950 0.87 CYP3A4 (0.54) TOP1TOP2AKDM4ECYP3A4CYP2C9
SCHEMBL7008772 0.86 CYP3A4 (0.61) TOP1TOP2AKDM4ECYP3A4CYP2C9
SCHEMBL7004804 0.86 CYP3A4 (0.71) TOP1TOP2ACYP3A4CYP2C9ALDH1A1
SCHEMBL7009205 0.85 CYP3A4 (0.60) TOP1TOP2ACYP3A4CYP2C9ALDH1A1
SCHEMBL8479016 0.85 ALDH1A1 (0.69) TOP1TOP2ACYP3A4CYP2C9ALDH1A1
SCHEMBL7005992 0.85 CYP3A4 (0.58) TOP1TOP2ACYP3A4CYP2C9ALDH1A1
SCHEMBL7004969 0.85 ALDH1A1 (0.69) TOP1TOP2ACYP3A4CYP2C9ALDH1A1
SCHEMBL8484766 0.85 CYP3A4 (0.58) TOP1TOP2AKDM4ECYP3A4CYP2C9
SCHEMBL7007374 0.85 CYP3A4 (0.58) TOP1TOP2ACYP3A4CYP2C9ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5910498-A NOVEL COMPOUNDS HAVING REDUCED CYTOTOXICITY, PHOTOTOXICITY; TREATING BACTERIAL AND VIRAL INFECTIONS WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1999-06-08 US disclosed
EP-0787720-A1 NOVEL PYRIDONECARBOXYLATE DERIVATIVE OR SALT THEREOF AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1997-08-06 EP disclosed