Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.52 |
| ▸ | TOP2A | P11388 | 3/20 | 0.51 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TOP1 | P11387 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009985 | 0.89 | CHRM1 (0.61) | CHRM1KDM4ELMNAMAPTTOP1 | |
| SCHEMBL7006634 | 0.87 | CHRM1 (0.56) | CHRM1KDM4ELMNAALDH1A1POLB | |
| SCHEMBL7007769 | 0.83 | KDM4E (0.60) | CHRM1TOP2ATOP2BKDM4ELMNA | |
| SCHEMBL500481 | 0.81 | KDM4E (0.69) | CHRM1TOP2ATOP2BKDM4ELMNA | |
| SCHEMBL7011663 | 0.80 | KDM4E (0.58) | CHRM1TOP2ATOP2BKDM4ELMNA | |
| SCHEMBL9148996 | 0.80 | KDM4E (0.45) | CHRM1TOP2ATOP2BKDM4ELMNA | |
| SCHEMBL11185169 | 0.79 | KDM4E (0.60) | TOP2ATOP2BKDM4ELMNAALDH1A1 | |
| SCHEMBL500816 | 0.79 | KDM4E (0.61) | KDM4ELMNAALDH1A1POLBHSP90AA1 | |
| SCHEMBL30843076 | 0.79 | KDM4E (0.61) | KDM4ELMNAALDH1A1POLBHSP90AA1 | |
| SCHEMBL7008956 | 0.79 | KDM4E (0.47) | CHRM1TOP2ATOP2BKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0614664-B2 | Quinolonecarboxylic acid derivatives, their preparation and their use as cell adhesion inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-5889009-A | ADMINISTERING 1,7-DISUBSTITUTED-4-OX-3-(QUINOLINECARBOXYLIC ACID OR NAPHTHYRIDINECARBOXYLIC ACID) | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-30 | — | — | US | disclosed |
| EP-0614664-B1 | Quinolonecarboxylic acid derivatives, their preparation and their use as cell adhesion inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-09-16 | — | — | EP | disclosed |
| US-5703081-A | CELL ADHESION INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-30 | — | — | US | disclosed |
| US-5519024-A | CELL ADHESION INHIBITOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-05-21 | — | — | US | disclosed |
| EP-0614664-A1 | Quinolonecarboxylic acid derivatives, their preparation and their use as cell adhesion inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-09-14 | — | — | EP | disclosed |