Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 2/20 | 0.39 |
| ▸ | EDNRA | P25101 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007654 | 0.93 | MCL1 (0.40) | EDNRBEDNRARORCMCL1MAPT | |
| SCHEMBL7009283 | 0.90 | EDNRB (0.40) | EDNRBEDNRARORCMCL1MAPT | |
| SCHEMBL7010894 | 0.88 | MCL1 (0.38) | EDNRBEDNRARORCMCL1MAPT | |
| SCHEMBL9407273 | 0.87 | MAPT (0.38) | EDNRBEDNRAMCL1MAPTPOLB | |
| SCHEMBL7009200 | 0.87 | EDNRB (0.38) | EDNRBEDNRARORCMCL1MAPT | |
| SCHEMBL7006390 | 0.87 | MCL1 (0.37) | EDNRBEDNRARORCMCL1MAPT | |
| SCHEMBL7008566 | 0.86 | GAA (0.37) | EDNRBEDNRAMCL1MAPTPOLB | |
| SCHEMBL7012773 | 0.85 | EDNRB (0.36) | EDNRBEDNRAMCL1MAPTPOLB | |
| SCHEMBL8326182 | 0.85 | EDNRB (0.45) | EDNRBEDNRARORCMCL1MAPT | |
| SCHEMBL8321015 | 0.85 | EDNRA (0.45) | EDNRBEDNRAMCL1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601386-B1 | Sulphonamides | HOFFMANN LA ROCHE (CH) | 2003-02-05 | — | — | EP | claimed |
| EP-0601386-A1 | Sulphonamides | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | claimed |
| EP-0601386-B1 | Sulphonamides | HOFFMANN LA ROCHE (CH) | 2003-02-05 | — | — | EP | disclosed |
| EP-0601386-A1 | Sulphonamides | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |