Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | EDNRB | P24530 | 2/20 | 0.34 |
| ▸ | EDNRA | P25101 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7010894 | 0.90 | MCL1 (0.38) | GAAMCL1HTTLMNAEDNRB | |
| SCHEMBL7007654 | 0.89 | MCL1 (0.40) | GAAMCL1EDNRBEDNRAMEN1 | |
| SCHEMBL7006390 | 0.89 | MCL1 (0.37) | GAAMCL1HTTLMNAEDNRB | |
| SCHEMBL7012773 | 0.88 | EDNRB (0.36) | GAAMCL1HTTLMNANPSR1 | |
| SCHEMBL7011111 | 0.86 | EDNRB (0.39) | MCL1EDNRBEDNRAMEN1KMT2A | |
| SCHEMBL9407273 | 0.84 | MAPT (0.38) | GAAMCL1HTTLMNAEDNRB | |
| SCHEMBL7006907 | 0.83 | EDNRA (0.42) | GAAHTTLMNAEDNRBEDNRA | |
| SCHEMBL7009283 | 0.83 | EDNRB (0.40) | GAAMCL1HTTLMNAEDNRB | |
| SCHEMBL8321015 | 0.82 | EDNRA (0.45) | GAAMCL1HTTLMNAEDNRB | |
| SCHEMBL7013541 | 0.81 | LMNA (0.34) | MCL1LMNAEDNRBEDNRAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601386-B1 | Sulphonamides | HOFFMANN LA ROCHE (CH) | 2003-02-05 | — | — | EP | claimed |
| EP-0601386-A1 | Sulphonamides | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | claimed |
| EP-0601386-B1 | Sulphonamides | HOFFMANN LA ROCHE (CH) | 2003-02-05 | — | — | EP | disclosed |
| EP-0601386-A1 | Sulphonamides | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |