SCHEMBL7011353

CNC(=O)c1ccc(C=CC(=O)Nc2cccc(-c3ccc(C)c(COc4cccc5ccc(C)nc45)c3C)c2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	BDKRB2	P30411	18/20	0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL7011358	1.00	BDKRB2 (0.70)	BDKRB2
SCHEMBL8015041	0.85	BDKRB2 (0.59)	BDKRB2
SCHEMBL8015038	0.85	BDKRB2 (0.59)	BDKRB2
SCHEMBL7014199	0.84	BDKRB2 (0.60)	BDKRB2
SCHEMBL7014202	0.84	BDKRB2 (0.60)	BDKRB2
SCHEMBL7012774	0.83	BDKRB2 (1.00)	BDKRB2
SCHEMBL7012778	0.83	BDKRB2 (1.00)	BDKRB2
SCHEMBL7016917	0.82	BDKRB2 (0.49)	BDKRB2
SCHEMBL7014316	0.81	NPC1 (0.48)	BDKRB2
SCHEMBL7014321	0.81	NPC1 (0.48)	BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0861243-B1	HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS	FUJISAWA PHARMACEUTICAL CO (JP)	2003-11-12	—	—	EP	disclosed
US-6344462-B1	Heterocyclic compounds as bradykinin antagonists	FUJISAWA PHARMACEUTICAL CO., LTD. (JP)	2002-02-05	—	—	US	disclosed
US-6100284-A	ANTIALLERGENS	FUJISAWA PHARMACEUTICAL CO., LTD. (JP)	2000-08-08	—	—	US	disclosed
US-6008229-A	TREATING ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASE, SHOCK, PAIN	FUJISAWA PHARMACEUTICAL CO., LTD. (JP)	1999-12-28	—	—	US	disclosed