Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 5/20 | 0.65 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.65 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.54 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 13/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005917 | 0.92 | TOP2A (0.63) | TOP2ATOP2BCACNA1FPOLBMAPK1 | |
| SCHEMBL7006682 | 0.90 | TOP2A (0.55) | TOP2ATOP2BCACNA1FPOLBMAPK1 | |
| SCHEMBL7012074 | 0.88 | TOP2A (0.51) | TOP2ATOP2BCACNA1FPOLBMAPK1 | |
| SCHEMBL7098947 | 0.87 | TOP2A (0.53) | TOP2ATOP2BCACNA1FPOLBMAPK1 | |
| SCHEMBL7012570 | 0.86 | TOP2A (0.67) | TOP2ATOP2BCACNA1FPOLBMAPK1 | |
| SCHEMBL7005848 | 0.83 | TOP2A (0.51) | TOP2ATOP2BCACNA1FPOLBMAPK1 | |
| SCHEMBL7010234 | 0.83 | TOP2A (0.73) | TOP2ATOP2BPOLBKCNH2GSK3B | |
| SCHEMBL7008547 | 0.79 | TOP2A (0.63) | TOP2ATOP2BPOLBKCNH2GSK3B | |
| SCHEMBL7013280 | 0.78 | TOP2A (0.42) | TOP2ATOP2BCACNA1FPOLBMAPK1 | |
| SCHEMBL4998787 | 0.78 | TOP2A (0.55) | TOP2ATOP2BPOLBKCNH2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775702-B1 | NOVEL QUINOLONE- OR NAPHTHYRIDONECARBOXYLIC ACID DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO LTD (JP) | 2003-07-23 | — | — | EP | disclosed |
| US-5935952-A | ANTIBACTERIAL AGENT | TOYAMA CHEMICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0775702-A1 | NOVEL QUINOLONE- OR NAPHTHYRIDONECARBOXYLIC ACID DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 1997-05-28 | — | — | EP | disclosed |