Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20640153 | 0.88 | MMP2 (0.42) | KMT2ACA2CA1MMP1MMP2 | |
| SCHEMBL3131619 | 0.88 | MMP2 (0.42) | KMT2ACA2CA1MMP1MMP2 | |
| SCHEMBL23668257 | 0.88 | MMP2 (0.42) | KMT2ACA2CA1MMP1MMP2 | |
| SCHEMBL4751494 | 0.79 | PRMT5 (0.53) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL4754054 | 0.79 | PRMT5 (0.53) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL4754049 | 0.79 | PRMT5 (0.53) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL4751497 | 0.79 | PRMT5 (0.53) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL14974360 | 0.78 | NR1H2 (0.49) | PRMT5WDR77FKBP1AMAPK1MMP2 | |
| SCHEMBL2107851 | 0.78 | NR1H2 (0.49) | PRMT5WDR77FKBP1AMAPK1MMP2 | |
| SCHEMBL2685496 | 0.78 | NR1H2 (0.49) | PRMT5WDR77FKBP1AMAPK1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |